Chandy C. John, M.D., M.S.

Associate Professor
Department of Pediatrics
Division of Pediatric Infectious Diseases
Director of the Global Pediatrics Program

Our lab focuses on three major problem areas in malaria: 1) the relationship of changing transmission conditions to the development of immunity in malaria; 2) environmental predictors of malaria risk in epidemic-prone areas; and 3) the pathogenesis of cerebral malaria, with a particular focus on how the immune response to malaria relates to long-term neurologic and cognitive impairment in children with cerebral malaria. Our malaria research studies are done in collaboration with colleagues at the Kenya Medical Research Institute in Kisumu, Kenya and Makerere University/Mulago Hospital in Kampala, Uganda.

Selected publications:

Boivin MJ, Bangirana P, Opoka RO, Byarugaba J, Idro R, Jurek AM, John CC. Cognitive impairment following cerebral malaria in children: a prospective study. Pediatrics 2007;119:e360-366.

Ernst KC, Adoka SO, Kowuor D, Wilson ML, John CC. Malaria hotspot areas in a highland Kenya site are consistent in epidemic and non-epidemic years and are associated with ecological factors. Malaria Journal 2006; 5:78.

John CC, O¿Donnell RA, Sumba PO, Moormann AM, deKoenig-Ward TF, King CL, Kazura JW, Crabb BS. Evidence that invasion-inhibitory antibodies specific for MSP-119 can play a protective role against blood-stage Plasmodium falciparum infection in individuals in a malaria endemic area of Africa. J Immunology 2004;173:666-672.

Other links

http://www.peds.umn.edu/globalpediatrics