Stephen J. McSorley, PhD

Associate Professor
Department of Medicine
Division of Gastroenterology, Hepatology, and Nutrition

Salmonella typhi causes typhoid fever, a common infection in many developing nations. Current typhoid vaccines are only moderately effective or unsafe for use by the very young or elderly. Research in our laboratory focuses on understanding the activation of innate and adaptive immune responses to Salmonella with a view to development of novel typhoid vaccines. Our laboratory is actively developing a novel model of antigen-specific colitis and attempting to identify how and where T cells responsive to normal enteric flora are activated in vivo.

Selected publications:

Ravindran, R., J. Foley, T. Stoklasek, L.H. Glimcher, and S.J. McSorley. (2005) Expression of T-bet by CD4 T cells is essential for resistance to Salmonella infection. J. Immunol. 174:4603.

Salazar-Gonzalez, R.M., J.H. Niess, D.J. Zammit, R. Ravindran, A. Srinivasan, J.R. Maxwell, T. Stoklasek, R. Yadav, I.R. Williams, X. Gu, B.A. McCormick, M.A. Pazos, A.T. Vella, L. Lefrancois, H-C. Reinecker, and S.J. McSorley. (2006) CCR6-mediated dendritic cell activation of pathogen-specific T cells in Peyer_s patches. Immunity 24:623.

Srinivasan, A., Salzar-Gonzalez, R, Jarcho, M., Lefrancois, L., and S.J. McSorley. (2007) Innate immune activation of CD4 T cells in Salmonella-infected mice is dependent on IL-18. J. Immunol. 178:4342.

Ravindran, R., Rusch, L., Jarcho, M., Itano, A. Jenkins, M.K., and S.J. McSorley. (2007) CCR6-dependent recruitment of blood phagocytes is necessary for rapid CD4 T cell responses to local bacterial infection. Proc. Natl. Acad. Sci. 104:12075.

Other links

http://www.micab.umn.edu/faculty/McSorley.html
http://www.med.umn.edu/gi/faculty/mcsorley.html
http://www.immunology.umn.edu/immunology/members/home.html