Paul Bohjanen, M.D., Ph. D.
Departments of Microbiology and Medicine
Dr. Bohjanen received his M.D., Ph.D. degree from the University of Michigan in 1993. He then pursued residency training in internal medicine and fellowship training in infectious diseases at Duke University. He has been a member of the faculty at the University of Minnesota since 2000 and became a Co-Director of CIDMTR in 2007. Dr. Bohjanen has a clinical interest in HIV infection and the global AIDS epidemic. His laboratory research is directed at understanding the regulation of gene expression in cells of the immune system and the abnormal regulation of gene expression that occurs in patients with HIV infection. Basic research studies in Dr. Bohjanen's laboratory focus on the role of mRNA decay in regulating T lymphocyte activation and function. One mechanism that cells use to turn off gene expression is specific mRNA decay within the cytoplasm. Dr. Bohjanen is working to understand the biochemical mechanisms that regulate mRNA decay and to understand the role of mRNA decay in regulating gene expression in disease states such as malignancy or virus infection. Recently, Dr. Bohjanen has applied his expertise in immune cell gene expression to understand the pathogenesis of HIV immune reconstitution inflammatory syndrome (IRIS), an important complication of antiretroviral therapy (ART) that has recently emerged in Africa. Dr. Bohjanen's laboratory has developed a collaborative project with the Infectious Diseases Institute at Makerere University in Kampala, Uganda to prospectively follow HIV-infected patients after they initiate antiretroviral therapy and to compare immune activation in patients that do or do not develop IRIS. These studies will identify biomarkers that can be used to diagnose, predict, or monitor IRIS and will provide insight into the pathophysiology of IRIS that will allow the development of better treatments.
For more about Dr. Bohjanen's research, see his Laboratory Web Page.
- I. A. Vlasova, N. M. Tahoe, D. Fan, B. Rattenbacher, J. R. SternJohn, O. Larsson, J. Vasdewani, G. Karypis, C. S. Reilly, P. Bitterman, and P. R. Bohjanen. 2007. Conserved GU-rich elements mediate mRNA decay by binding to CUG-binding protein 1. Molec. Cell In press.
- D.R. Boulware and P.R. Bohjanen. 2007. Chapter 18: HIV Immune Reconstitution Inflammatory Syndrome. In: Global HIV/AIDS Medicine. M. Sande, P. Volberding, J. Lange, and W. Greene, Eds. Elsevier, Philadelphia. pp. 193-205.
- H. H. Hau, R. Walsh, R.L. Ogilvie, C.S. Reilly, and P.R. Bohjanen. 2007. Tristetraprolin recruits functional mRNA decay complexes to ARE sequences. J. Cell. Biochem. 100:1477-92.
- J. Baker, D. Boulware, and P.R. Bohjanen. 2006. A Case For Treating High Hepatitis B DNA Levels Prior to Starting HIV Therapy. AIDS 20:2402-3.